Division of General Education - Natural SciencesBiology

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190522_003

We are in charge of the subject of Life Science and special programs for first-year students.
In our research activities, the goal is to understand how galectins, a family of β-galactoside binding lectin, modulate animal development and the immune system. The molecular mechanisms of galectin action may be determined by the recognition of glycoproteins and/or protein-protein interaction that can transduce multi-signals in biological nature.
We aim to:
(1) Identify the role of galectins in development, especially placentation using human specimens, rat and mouse models.
(2) Reveal the function of galectins in immunity, especially anti-viral infection and autoimmune diseases using the murine disease model.

Contact Information

TEL: / FAX: / Email: hirokis@kanazawa-med.ac.jp

Faculty

Professor

  • SHOJI Hiroki 東海林先生

Senior Assistant Professor

  • SAKAI Daisuke

Research Achievements

Research Activities

  • Ogoh H, Yamagata K, Nakao T, Sandell LL, Yamamoto A, Yamashita A, Tanga N, Suzuki M, Abe T, Kitabayashi I, Watanabe T and Sakai D (2017) Mllt10 knockout mouse model reveals critical role of Af10-dependent H3K79 methylation in midfacial development. Sci Rep 7(1):11922.
  • Arikawa T, Liao S, Shimada H, Inoue T, Sakata-Haga H, Nakamura T, Hatta T, Shoji H (2016) Galectin-4 expression is down-regulated in response to autophagy during differentiation of rat trophoblast cells. Sci Rep. 6:32248.
  • Sakai D, Dixon J, Achilleos A, Dixon M, and Trainor PA. (2016) Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation. Nat Commun. 7, 10328
  • Arikawa T, Simamura E, Shimada H, Nakamura T, Hatta T, Shoji H (2014) Significance of sugar chain recognition by galectins and its involvement in disease-associated glycosylation. Congenit Anom (Kyoto). 54 (2): 77-81.
  • Arikawa T, Simamura E, Shimada H, Nishi N, Tatsuno T, Ishigaki Y, Tomosugi N, Yamashiro C, Hata T, Takegami T, Mogami H, Yamaguchi K, Nakamura T, Otani H, Hatta T, Shoji H. (2012) Expression pattern of Galectin 4 in rat placentation. Placenta. 33: 885-7

External Research Funding

  • Grant-in-Aid for Scientific Research (C) 2019-2022 (19K06680) to Daisuke Sakai from the Japan Society for Promotion of Science (JSPS)
  • Grant-in-Aid for Scientific Research (C) 2017-2019 (17K11258) to Hiroki Shoji from the Japan Society for Promotion of Science (JSPS)
  • Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area) 2017-2019 (17H05965) to Daisuke Sakai from the Japan Society for Promotion of Science (JSPS)
  • Grant-in-Aid for Scientific Research (C) 2014-2016 (26462502) to Hiroki Shoji from the Japan Society for Promotion of Science (JSPS)
  • Grant-in-Aid for Scientific Research (C) 2011-2013 (23592423) to Hiroki Shoji from the Japan Society for Promotion of Science (JSPS)